Trials for Preventing Dementia
If you test positive for the gene APOE4, you may be eligible for the CAD106 and CNP520 study.
Contact:
Brain Matters Research
Delray Beach, Florida, United States, 33445 Contact 561-381-9060 jlesmes@brainmattersresearch.com
If you test positive for the gene ApoE4, you may be eligible for infusions from noncarriers (ApoE3) at the Mayo a clinic in Jacksonville.
Study Name: Plasmapheresis Versus Plasma Infusion From Young APOE3 Homozygotes Into MCI APOE4 Homozygotes to Slow Disease Progression
Contact:
Mayo Clinic in FloridaJacksonville, Florida, United States, 32224
800-664-4542
If you are worried about your memory, it is best to see a cognitive neurologist before enrolling in a trial. A Clinical Trial is not a substitute for medical advice, accurate diagnosis, or treatment.
If you also also interested in a trial, you may also be eligible for photobiomodulation, which is an intranasal device to increase brain activity. It stimulates cells to generate more energy and undergo self-repair through the use of near infrared light (NIR). Also known as low-level light (or laser) therapy, PBM has no side effects. Occasionally, first time users may experience a transient headache, dry throat, or tiredness
Contact: Dawn Bowers, Ph.D.352-392-3450dawnbowers@phhp.ufl.eduContact: Paul Mangal, M.S.352-392-3450pmangal@phhp.ufl.edu
Locations
The Center for Movement Disorders and Neurorestoration
Gainesville, FL 32607 Contact: Dawn Bowers, Ph.D. 352-273-6152 dawnbowers@phhp.ufl.edu
The Village Retirement Community, The Villages, FL 32653 Contact: Dawn Bowers, Ph.D. 352-392-3450 dawnbowers@phhp.ufl.edu Contact: Michael Marsiske, Ph.D 352-392-3450 marsiske@phhp.ufl.edu
If you are worried about your memory, you may also be eligible for a trial of the nicotine patch.
Contact:
Brain Matters Research
Delray Beach, Florida, United States, 33445 Contact: Jetliza Lesmes 561-374-8461 ext 110 jlesmes@brainmattersresearch.com Principal Investigator: Mark Brody, MD, CPI
You may also be eligible for a comprehensive exercise and cognitive engagement program at the University of Florida.
Contacts
Glenn E. Smith, Ph.D.352-273-6556glennsmith@phhp.ufl.eduContact: Liselotte De Wit, M.S.352-294-8674ldewit@phh.ufl.edu
United of Florida Gainesville, Florida, United States, 32611
Treating Alzheimer’s
Mild Alzheimer’s Disease
Anyone who has already been enrollled in the aducanumb study should continue participating! It has already shown a 25% reduced risk of progression in mild Alzheimer’s, and maybe more as the drug is infused for more months. It is currently up for FDA approval and we hope to begin prescribing it in the upcoming months!
Contact:
US Biogen Clinical Trial Center
633-4636-4636clinicaltrials@biogen.com
Like aducanumab, which has already shown a 25% reduction in symptoms, there are other immunizations against amyloid, the brain plaque involved in Alzheimer’s. These would be IV infusions of BAN2401 for people with mild Alzheimer’s disease. Its safety has already been tested in previous trials.
Contact:
Visionary Investigators
Miami, Florida, United States, 33137
Eisai Medical Information1-888-274-2378 esi_medinfo@eisai.com
I am very excited about immunizations against tau, the tangles involved in Alzheimer’s Diseases. These tau tangles are more correlated with the symptoms of Alzheimer’s, and may be the direct cause for people with other forms of dementia, such as Chrinic Traumatic Encephalopathy (Football Player’s Dementia), some types of Parkinson’s Dementia, Frontotemporal Dementia, and Primary Progressive Aphasia. So, Tau trials have the chance to significantly treat most forms of dementia!
The Goserunumab infusion trial is for people with mild Alzheimer’s disease.
Contact:
Brain Matters ResearchDelray Beach, Florida, United States, 33445
5613748461
The Garentunumab infusion trial is for people with mild Alzheimer’s Disease.
Infinity Clinical Research, LLC
Sunrise, Florida, United States, 33351
3537 N. Pine Island Road Sunrise, Florida 33351
Tel 954-475-8171
For Mild Cognitive Impairment of the Amnestic Type, there are actually trials to implant a Vagal Nerve Stimulator Device in the brain (similar to a pacemaker), just as it helps people with Epilepsy.
University of Florida, Gainesville, Florida, United States, 32610
Contact: Aidan J Murphy, B.A. 352-548-6000 ext 103329 aidanjmurphy@phhp.ufl.edu
For Mild Alzheimer’s Disease patients, there is an implantable device (like a pacemaker) called fornix-Deep Brain Stimulation to improve memory. They are already using this in Parkinson’s with wonderful results that last for decades.
Contact:
University of Florida
Gainesville, Florida, United States, 32601 Contact: Camille Swartz 352-273-5612 Cami.Swartz@neurology.ufl.edu
or
University of South Florida
Tampa, Florida, United States, 33613 Contact: Julie Samson 813-974-1201 jsamson@health.usf.edu
Mild to Moderate Alzheimer’s
The Semorinemab trial is for people with mild to moderate Alzheimer’s Disease. This has already been tested for patient safety.
Contact:
Brain Matters Research, Inc.
Delray Beach, Florida, United States, 33445
561-381-9060 jlesmes@brainmattersresearch.com
I am also very excited about pills against tau. If infusions are too scary, I would recommend the TRx0237 trial, which is a pill against tau for people with mild to moderate Alzheimer’s.
Contact:
MD Clinical
Not yet recruiting as of Feb 2020
Hallandale Beach, Florida, United States, 33160
(954)455-5757
(954) 455-5859
For people with mild to moderate Alzheimer’s who don’t want infusions, I also highly recommend the GAIN trial, which is a pill that stops inflammation in the mouth to reaching the brain. Its safety has already been tested in previous trials.
Contact:
MD Clinical
Hallandale Beach, Florida, United States, 33009
Contact: Evelyn Quiles 954-455-5757 ext 111 equiles@mdclinical.org
There are new pills to decrease brain inflammation which may cause Alzheimer‘s Disease, including the pill ORY2001.
Contact:
Alzheimer's Research and Treatment Center
Lake Worth, Florida, United States, 33449 Contact: David Watson, Psy. D
561-209-2400
Photobiomodulation is also a very promising device for stimulating the brains of Alzheimer‘s Patients.
This is up in Gainesville at University of Florida where I trained.
Contact: Dawn Bowers, Ph.D.
352-273-6152dawnbowers@phhp.ufl.edu
Adam J Woods, Ph.D.352-294-5852 ajwoods@phhp.ufl.edu
Moderate Alzheimer’s
For patients with moderate Alzheimer‘s Disease, the pill PTI-125 may help remove tau and amyloid. Its safety has already been tested in humans.
IMIC, Inc.
Palmetto Bay, Florida, United States, 33157 Contact: Minela Sulijicic-Martinez 786-310-7477 minela@aktamedika.com
For patients with moderate Alzheimer’s Disease, the pill AR1001 may also help protect against progression. It’s safety has already been tested in humans.
Contact:
IMIC, Inc
Palmetto Bay, Florida, United States, 33157 Contact: Evelyn Lopez-Brignoni, MD 786-310-7477 evelyn@aktamedika.com
Severe Alzheimer’s
For any type of Alzheimer’s Disease, zagotenemab infusions against tau are also possible.
Contact:
Infinity Clinical Research, LLC. 3537 N. Pine Island Road Sunrise, Florida 33351
Tel 954-475-8171
There are also Lithium trials which are very promising. This is very safe and has been used for decades in bipolar disorder. This can also be prescribed off-label by me without going through a clinical trial.
Contact:
Uniberisty of Miami Miller School of Medicine
Miami, Florida, United States, 33136 Elizabeth Crocco, MD 305-355-9065 ecrocco@med.miami.edu
There are GRF6019 infusions as well for Severe Alzheimer‘s patients. Its safety has already been tested in humans, and may be associated with stabilization of cognition. It infuses the plasma of people with low risk of Alzheimer’s into the blood of severe Alzheimer’s patients.
Contact:
Riverside Clinical ResearchEdgewater, Florida, United States, 32132
386-428-7730
Trails for Vascular Cognitive Impairment
For people with Vascular Cognitive Impairment, there are brain-training trials that may help cognition, such as the Active Mind Trial.
University of South Florida
Tampa, Florida, 33620
Contact: Cognitive Aging Lab 813-974-6703 Principal Investigator: Jerri Edwards, PhD
However, there are no trials specifically aimed to treat Vascular Cognitive Impairment.
Trials for Lewy Body Disease or Parkinson’s Disease Dementia
The pill E2027 may be promising for improving cognition in Lewy Body. It already has been tested in humans for safety.
Contact:
Elias Research Associates (Allied Biomedical Research Institute)
Miami, Florida, United States, 33155 Pharmax Research of South Florida; Elias Research AssociatesMiami, Florida, United States, 33175
Contact:
PH: 208-346-8900
LY3154207 is a pill which may also be promising for stimulating dopamine in people with Lewy Body Dementia. It may improve cognition in people with Lewy body.
Visionary Investigators Network -VIN-Margarita Almeida
Pembroke Pines, Florida, United States, 33026 Contact 9548740201 Principal Investigator: Margarita Almeida El-Ramey
There are also antibody infusions against the proteins involved in Parkinson's and Lewy Body Disease (alpha-synuclein) but the trials are now only available in Japan.
Contact: US Biogen Clinical Trial Center866-633-4636clinicaltrials@biogen.com
For those with mild stage Lewy Body Disease or mild cognitive symptoms due to Parkinson’s Disease, the NYX-458 pill may improve cognition. However, it has never been tested in humans, and this study is primarily to determine safety in humans.
Contact: Aptinyx Clinical Site
847-871-0377 ext1 clinicalstudies@aptinyx.com
Hallandale Beach, Florida, United States, 33009
Trials for Traumatic Brain Injury
There are treatments to help the psychological symptoms of Chronic Post-Concussion Syndrome, such as cognitive dysfunction, anxiety, catastrophizing, hyper vigilance, and help balance the sympathetic/parasympathetc symptoms.
Contact:
University of California, Los Angeles
Los Angeles, California, United States, 90095 Contact: Aliyah R Snyder, PhD 310-825-9121 asnyder@mednet.ucla.edu Contact: Alexandra Tanner, MS tannera@ucla.edu
There is brain training for improving cognitive abilities in Traumatic Brain Injury.
Contact: Catherine Tocci, B.A.352-294-0336ctocci1@ufl.edu
William Perlstein, Ph.D.352-273-6139wmp@ufl.edu
College of Public Health and Health Professions, University of FloridaGainesville, Florida, United States, 32611
There is neuromodulation stimulation for Traumatic Brain Injury called the PoNS program, which involves a combination of symptom specific physical exercises and repeated use of the PoNS device.
Contact: Denise McDermott5162970864dmcdermo@northwell.edi
North Shore University Hospital
Manhasset, New York, United States, 11030
There is also a pill called AVP-786 being used to treat aggression, agitation, and irritability in Traumatic Brain Injury.
Premier Clinical Research Institute, Inc
Miami, Florida, United States, 33122
305-392-0279
There is a trial for hyperbaric oxygen therapy in Severe Traumatic Brain Injury for improving level of consciousness.
St. Mary's Medical Center
West Palm Beach, FL 33407
Contact: Magdolna Pakcos magdolna.pakocs@tenethealth.com
If you have had a concussion or multiple concussions and are worried about dementia or CTE, there is a trial in Canada studying the brains of those with concussions to determine the brain injuries that may or may not lead to CTE.
Canadian Concussion Centre, Toronto Western Hospital, University Health Network
Toronto, Ontario, Canada, M6J 3S3 Contact: Mozhgan Khodadadi, MA 416-603-5800 ext 4025 Mozhgan.Khodadadi@uhn.ca
Trials for Chronic Traumatic Encephalopathy
Currently, there are no studies to treat CTE, but rather to diagnose it earlier in life. For former football players, please contact:
Boostin University School of Medicine
Boston, Massachusetts, United States, 02118 Contact: Robert Stern, PhD 617-358-5375 bobstern@bu.edu Contact: Megan Mariani 617-358-5605 mmariani@bu.edu
There are treatments to help the psychological symptoms of Chronic Post-Concussion Syndrome, such as cognitive dysfunction, anxiety, catastrophizing, hyper vigilance, and help balance the sympathetic/parasympathetc symptoms.
Contact:
University of California, Los Angeles
Los Angeles, California, United States, 90095 Contact: Aliyah R Snyder, PhD 310-825-9121 asnyder@mednet.ucla.edu Contact: Alexandra Tanner, MS tannera@ucla.edu
If you have had a concussion or multiple concussions and are worried about dementia or CTE, there is a trial in Canada studying the brains of those with concussions to determine the brain injuries that may or may not lead to CTE.
Canadian Concussion Centre, Toronto Western Hospital, University Health Network
Toronto, Ontario, Canada, M6J 3S3 Contact: Mozhgan Khodadadi, MA 416-603-5800 ext 4025 Mozhgan.Khodadadi@uhn.ca
However, please note that there may be several off-label treatments for CTE that you can ask a Cognitive Neurologist about.
Trials for Frontotemporal Dementia
Infusions of the AL001 antibody against progranulin have never been tested in humans before, but seem promising.
Contact: 4152315660 ext 328 info@alector.com
or UCSF, San Francisco, California, United States, 94158
Contact: 415-514-5745 lauren.fisher@ucsf.edu or 415-476-0661 mary.koestler@ucsf.edu
Intranasal Insulin may be a promising treatment.
Contact: Maria Pyle 651-495-6363 Maria.X.Pyle@HealthPartners.com
Contact: Sharon Hwee 651-495-6363 Sharon.X.Hwee@HealthPartners.com
Locations: HealthPartners Neuroscience Center
Saint Paul, Minnesota, United States, 55130 Contact: Clinical Trial Coordinator 651-495-6363
Low-dose lithium is also very promising for many types of neurodegeneration, including FTD.
Contact: Columbia University Medical Center
New York, New York, United States, 10032
Hannah E Silverman 212-305-6284 hs2971@cumc.columbia.edu
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