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Trials for Preventing and Treating Dementia


Trials for Preventing Dementia

If you test positive for the gene APOE4, you may be eligible for the CAD106 and CNP520 study.

Contact:

Brain Matters Research

Delray Beach, Florida, United States, 33445 Contact    561-381-9060 jlesmes@brainmattersresearch.com


If you test positive for the gene ApoE4, you may be eligible for infusions from noncarriers (ApoE3) at the Mayo a clinic in Jacksonville.

Study Name: Plasmapheresis Versus Plasma Infusion From Young APOE3 Homozygotes Into MCI APOE4 Homozygotes to Slow Disease Progression

Contact:

Mayo Clinic in FloridaJacksonville, Florida, United States, 32224

800-664-4542


If you are worried about your memory, it is best to see a cognitive neurologist before enrolling in a trial. A Clinical Trial is not a substitute for medical advice, accurate diagnosis, or treatment.

If you also also interested in a trial, you may also be eligible for photobiomodulation, which is an intranasal device to increase brain activity. It stimulates cells to generate more energy and undergo self-repair through the use of near infrared light (NIR).  Also known as low-level light (or laser) therapy, PBM has no side effects.  Occasionally, first time users may experience a transient headache, dry throat, or tiredness

Contact: Dawn Bowers, Ph.D.352-392-3450dawnbowers@phhp.ufl.eduContact: Paul Mangal, M.S.352-392-3450pmangal@phhp.ufl.edu

Locations

The Center for Movement Disorders and Neurorestoration

Gainesville, FL 32607 Contact: Dawn Bowers, Ph.D.    352-273-6152    dawnbowers@phhp.ufl.edu

The Village Retirement Community, The Villages, FL 32653 Contact: Dawn Bowers, Ph.D.    352-392-3450    dawnbowers@phhp.ufl.edu Contact: Michael Marsiske, Ph.D    352-392-3450    marsiske@phhp.ufl.edu


If you are worried about your memory, you may also be eligible for a trial of the nicotine patch.

Contact:

Brain Matters Research

Delray Beach, Florida, United States, 33445 Contact: Jetliza Lesmes    561-374-8461 ext 110    jlesmes@brainmattersresearch.com Principal Investigator: Mark Brody, MD, CPI


You may also be eligible for a comprehensive exercise and cognitive engagement program at the University of Florida.

Contacts

Glenn E. Smith, Ph.D.352-273-6556glennsmith@phhp.ufl.eduContact: Liselotte De Wit, M.S.352-294-8674ldewit@phh.ufl.edu

United of Florida Gainesville, Florida, United States, 32611


Treating Alzheimer’s





Mild Alzheimer’s Disease

Anyone who has already been enrollled in the aducanumb study should continue participating! It has already shown a 25% reduced risk of progression in mild Alzheimer’s, and maybe more as the drug is infused for more months. It is currently up for FDA approval and we hope to begin prescribing it in the upcoming months!

Contact:

US Biogen Clinical Trial Center


Like aducanumab, which has already shown a 25% reduction in symptoms, there are other immunizations against amyloid, the brain plaque involved in Alzheimer’s. These would be IV infusions of BAN2401 for people with mild Alzheimer’s disease. Its safety has already been tested in previous trials.

Contact:

Visionary Investigators

Miami, Florida, United States, 33137

Eisai Medical Information1-888-274-2378 esi_medinfo@eisai.com



I am very excited about immunizations against tau, the tangles involved in Alzheimer’s Diseases. These tau tangles are more correlated with the symptoms of Alzheimer’s, and may be the direct cause for people with other forms of dementia, such as Chrinic Traumatic Encephalopathy (Football Player’s Dementia), some types of Parkinson’s Dementia, Frontotemporal Dementia, and Primary Progressive Aphasia. So, Tau trials have the chance to significantly treat most forms of dementia!


The Goserunumab infusion trial is for people with mild Alzheimer’s disease.

Contact:

Brain Matters ResearchDelray Beach, Florida, United States, 33445

5613748461


The Garentunumab infusion trial is for people with mild Alzheimer’s Disease.

Infinity Clinical Research, LLC

Sunrise, Florida, United States, 33351

3537 N. Pine Island Road Sunrise, Florida 33351

Tel 954-475-8171


For Mild Cognitive Impairment of the Amnestic Type, there are actually trials to implant a Vagal Nerve Stimulator Device in the brain (similar to a pacemaker), just as it helps people with Epilepsy.

University of Florida, Gainesville, Florida, United States, 32610

Contact: Aidan J Murphy, B.A.    352-548-6000 ext 103329    aidanjmurphy@phhp.ufl.edu

For Mild Alzheimer’s Disease patients, there is an implantable device (like a pacemaker) called fornix-Deep Brain Stimulation to improve memory. They are already using this in Parkinson’s with wonderful results that last for decades.

Contact:

University of Florida

Gainesville, Florida, United States, 32601 Contact: Camille Swartz    352-273-5612    Cami.Swartz@neurology.ufl.edu

or

 University of South Florida

Tampa, Florida, United States, 33613 Contact: Julie Samson    813-974-1201    jsamson@health.usf.edu


Mild to Moderate Alzheimer’s

The Semorinemab trial is for people with mild to moderate Alzheimer’s Disease. This has already been tested for patient safety.

Contact:

Brain Matters Research, Inc.

Delray Beach, Florida, United States, 33445


I am also very excited about pills against tau. If infusions are too scary, I would recommend the TRx0237 trial, which is a pill against tau for people with mild to moderate Alzheimer’s.

Contact:

MD Clinical

Not yet recruiting as of Feb 2020

Hallandale Beach, Florida, United States, 33160

(954)455-5757

(954) 455-5859


For people with mild to moderate Alzheimer’s who don’t want infusions, I also highly recommend the GAIN trial, which is a pill that stops inflammation in the mouth to reaching the brain. Its safety has already been tested in previous trials.

Contact:

MD Clinical

Hallandale Beach, Florida, United States, 33009

Contact: Evelyn Quiles    954-455-5757 ext 111    equiles@mdclinical.org     


There are new pills to decrease brain inflammation which may cause Alzheimer‘s Disease, including the pill ORY2001.

Contact:

Alzheimer's Research and Treatment Center

Lake Worth, Florida, United States, 33449 Contact: David Watson, Psy. D   

561-209-2400


Photobiomodulation is also a very promising device for stimulating the brains of Alzheimer‘s Patients.

This is up in Gainesville at University of Florida where I trained.

Contact: Dawn Bowers, Ph.D.

Adam J Woods, Ph.D.352-294-5852 ajwoods@phhp.ufl.edu


Moderate Alzheimer’s

For patients with moderate Alzheimer‘s Disease, the pill PTI-125 may help remove tau and amyloid. Its safety has already been tested in humans.

IMIC, Inc.

Palmetto Bay, Florida, United States, 33157 Contact: Minela Sulijicic-Martinez    786-310-7477    minela@aktamedika.com


For patients with moderate Alzheimer’s Disease, the pill AR1001 may also help protect against progression. It’s safety has already been tested in humans.

Contact:

IMIC, Inc

Palmetto Bay, Florida, United States, 33157 Contact: Evelyn Lopez-Brignoni, MD    786-310-7477    evelyn@aktamedika.com


Severe Alzheimer’s

For any type of Alzheimer’s Disease, zagotenemab infusions against tau are also possible.

Contact:

Infinity Clinical Research, LLC. 3537 N. Pine Island Road Sunrise, Florida 33351

Tel 954-475-8171


There are also Lithium trials which are very promising. This is very safe and has been used for decades in bipolar disorder. This can also be prescribed off-label by me without going through a clinical trial.

Contact:

Uniberisty of Miami Miller School of Medicine

Miami, Florida, United States, 33136 Elizabeth Crocco, MD    305-355-9065    ecrocco@med.miami.edu


There are GRF6019 infusions as well for Severe Alzheimer‘s patients. Its safety has already been tested in humans, and may be associated with stabilization of cognition. It infuses the plasma of people with low risk of Alzheimer’s into the blood of severe Alzheimer’s patients.

Contact:

Riverside Clinical ResearchEdgewater, Florida, United States, 32132

386-428-7730


Trails for Vascular Cognitive Impairment




For people with Vascular Cognitive Impairment, there are brain-training trials that may help cognition, such as the Active Mind Trial.

University of South Florida

Tampa, Florida, 33620

Contact: Cognitive Aging Lab    813-974-6703       Principal Investigator: Jerri Edwards, PhD


However, there are no trials specifically aimed to treat Vascular Cognitive Impairment.


Trials for Lewy Body Disease or Parkinson’s Disease Dementia




The pill E2027 may be promising for improving cognition in Lewy Body. It already has been tested in humans for safety.

Contact:

Elias Research Associates (Allied Biomedical Research Institute)

Miami, Florida, United States, 33155 Pharmax Research of South Florida; Elias Research AssociatesMiami, Florida, United States, 33175

Contact:

PH: 208-346-8900


LY3154207 is a pill which may also be promising for stimulating dopamine in people with Lewy Body Dementia. It may improve cognition in people with Lewy body.

Visionary Investigators Network -VIN-Margarita Almeida

Pembroke Pines, Florida, United States, 33026 Contact    9548740201       Principal Investigator: Margarita Almeida El-Ramey


There are also antibody infusions against the proteins involved in Parkinson's and Lewy Body Disease (alpha-synuclein) but the trials are now only available in Japan.

Contact: US Biogen Clinical Trial Center866-633-4636clinicaltrials@biogen.com


For those with mild stage Lewy Body Disease or mild cognitive symptoms due to Parkinson’s Disease, the NYX-458 pill may improve cognition. However, it has never been tested in humans, and this study is primarily to determine safety in humans.

Contact: Aptinyx Clinical Site

847-871-0377 ext1 clinicalstudies@aptinyx.com

Hallandale Beach, Florida, United States, 33009


Trials for Traumatic Brain Injury



There are treatments to help the psychological symptoms of Chronic Post-Concussion Syndrome, such as cognitive dysfunction, anxiety, catastrophizing, hyper vigilance, and help balance the sympathetic/parasympathetc symptoms.

Contact:

University of California, Los Angeles

Los Angeles, California, United States, 90095 Contact: Aliyah R Snyder, PhD    310-825-9121    asnyder@mednet.ucla.edu Contact: Alexandra Tanner, MS       tannera@ucla.edu


There is brain training for improving cognitive abilities in Traumatic Brain Injury.

Contact: Catherine Tocci, B.A.352-294-0336ctocci1@ufl.edu

William Perlstein, Ph.D.352-273-6139wmp@ufl.edu

College of Public Health and Health Professions, University of FloridaGainesville, Florida, United States, 32611


There is neuromodulation stimulation for Traumatic Brain Injury called the PoNS program, which involves a combination of symptom specific physical exercises and repeated use of the PoNS device.

Contact: Denise McDermott5162970864dmcdermo@northwell.edi

North Shore University Hospital

Manhasset, New York, United States, 11030


There is also a pill called AVP-786 being used to treat aggression, agitation, and irritability in Traumatic Brain Injury.

Premier Clinical Research Institute, Inc

Miami, Florida, United States, 33122

305-392-0279


There is a trial for hyperbaric oxygen therapy in Severe Traumatic Brain Injury for improving level of consciousness.

St. Mary's Medical Center

West Palm Beach, FL 33407

Contact: Magdolna Pakcos       magdolna.pakocs@tenethealth.com


If you have had a concussion or multiple concussions and are worried about dementia or CTE, there is a trial in Canada studying the brains of those with concussions to determine the brain injuries that may or may not lead to CTE.

Canadian Concussion Centre, Toronto Western Hospital, University Health Network

Toronto, Ontario, Canada, M6J 3S3 Contact: Mozhgan Khodadadi, MA    416-603-5800 ext 4025    Mozhgan.Khodadadi@uhn.ca


Trials for Chronic Traumatic Encephalopathy



Currently, there are no studies to treat CTE, but rather to diagnose it earlier in life. For former football players, please contact:

Boostin University School of Medicine

Boston, Massachusetts, United States, 02118 Contact: Robert Stern, PhD    617-358-5375    bobstern@bu.edu Contact: Megan Mariani    617-358-5605    mmariani@bu.edu


There are treatments to help the psychological symptoms of Chronic Post-Concussion Syndrome, such as cognitive dysfunction, anxiety, catastrophizing, hyper vigilance, and help balance the sympathetic/parasympathetc symptoms.

Contact:

University of California, Los Angeles

Los Angeles, California, United States, 90095 Contact: Aliyah R Snyder, PhD    310-825-9121    asnyder@mednet.ucla.edu Contact: Alexandra Tanner, MS       tannera@ucla.edu


If you have had a concussion or multiple concussions and are worried about dementia or CTE, there is a trial in Canada studying the brains of those with concussions to determine the brain injuries that may or may not lead to CTE.

Canadian Concussion Centre, Toronto Western Hospital, University Health Network

Toronto, Ontario, Canada, M6J 3S3 Contact: Mozhgan Khodadadi, MA    416-603-5800 ext 4025    Mozhgan.Khodadadi@uhn.ca


However, please note that there may be several off-label treatments for CTE that you can ask a Cognitive Neurologist about.


Trials for Frontotemporal Dementia



Infusions of the AL001 antibody against progranulin have never been tested in humans before, but seem promising.

Contact: 4152315660 ext 328 info@alector.com

or UCSF, San Francisco, California, United States, 94158

Contact: 415-514-5745    lauren.fisher@ucsf.edu or 415-476-0661    mary.koestler@ucsf.edu


Intranasal Insulin may be a promising treatment.

Contact: Maria Pyle 651-495-6363 Maria.X.Pyle@HealthPartners.com

Contact: Sharon Hwee 651-495-6363 Sharon.X.Hwee@HealthPartners.com

Locations: HealthPartners Neuroscience Center

Saint Paul, Minnesota, United States, 55130 Contact: Clinical Trial Coordinator    651-495-6363


Low-dose lithium is also very promising for many types of neurodegeneration, including FTD.

Contact: Columbia University Medical Center

New York, New York, United States, 10032

Hannah E Silverman    212-305-6284    hs2971@cumc.columbia.edu





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